The world's top-ranked nation have won 12 games on the spin and will use this friendly as preparation for their upcoming UEFA Nations League games with England and Iceland.
As many as 11,000 spectators could be allowed into the ground after the Belgian government lifted various restrictions.
Belgium were initially scheduled to play New Zealand on Thursday evening, but the friendly was called off due to coronavirus travel restrictions and a new opponent has been found.
This is the first of three games in six days for Roberto Martinez's side and the other two - the aforementioned clashes with England and Iceland - will take priority.
The Red Devils kicked off their UEFA Nations League Group A2 campaign with a 2-0 win in Denmark and 5-1 victory at home to Iceland last month.
Not since a 5-2 loss to Switzerland in November 2018 have Belgium failed to win a game, a run that they will undoubtedly be eager to prolong in their remaining 2020 fixtures.
Ivory Coast are the first non-European side Martinez's men have faced since their run to the 2018 World Cup semi-finals, so this will present a different type of test.
The Elephants are in action for the first time in 11 months owing to the coronavirus pandemic, with their most recent match seeing them lose 2-1 away to Ethiopia.
They beat Niger 1-0 in their game before that - Franck Kessie scoring the only goal - and they are third in their qualifying group for the 2021 Africa Cup of Nations.
Indeed, the defeat to Ethiopia ended a three match winning run for Ivory Coast, who appointed Patrice Beaumelle as their new head coach earlier this year.
Belgium form (all competitions): WWWWWW
Ivory Coast form (all competitions): WLWWWL
Real Madrid's Eden Hazard suffered yet another injury setback last month, but he has still been named in an extended 33-man squad by Martinez.
That includes a contingent of 10 Premier League players, including star man Kevin De Bruyne, but Belgium are expected to heavily rotate for this friendly.
Unlike their opponents, Ivory Coast are expected to field something close to the strongest XI available for the friendlies with Belgium and Japan.
AC Milan midfielder Kessie, on the scoresheet last time out, and Arsenal winger Nicolas Pepe are among those available for selection.
Belgium possible starting lineup:
Mignolet; Dendoncker, Denayer, Boyata; Meunier, Witsel, Praet, Castagne; Saelemaekers, Batshuayi, Carrasco
Ivory Coast possible starting lineup:
Gbohouo; Aurier, Bailly, Gbamin, Konan; Kessie, Sangare; Pepe, Zaha, Boga; Kouame
We say: Belgium 3-1 Ivory Coast
Both teams have more important fixtures on the horizon - UEFA Nations League matches for Belgium, AFCON qualifiers for Ivory Coast - but this should still be an entertaining game.
Belgium are on a superb winning run stretching back nearly two years, whereas Ivory Coast have not played yet in 2020, so we can only see one outcome in Brussels.