The Spanish champions are currently two points clear of Real Madrid at the summit, while Mallorca occupy 18th position, one point from the safety of 17th ahead of the return of Spain's top flight.
Mallorca secured a return to Spain's top flight by advancing through the Segunda Division playoffs last season, but Los Bermellones are facing a battle to secure their position at this level for the 2020-21 campaign.
Indeed, Vicente Moreno's side have only collected 25 points from their 27 league matches during the 2019-20 season, leaving them 18th in the table with 11 games left.
Mallorca's position is far from terminal as they are only a point off 17th-placed Celta Vigo, while they have won seven league games this season, which is relatively high considering their spot in the table.
Their form prior to the lockdown period was strong, meanwhile, suffering just one defeat in their last four matches, recording two wins in the process, including a 2-1 success at Eibar last time out.
The omens are not exactly terrific for Mallorca, though, as they have lost their last six La Liga matches with Barca and have not been victorious against the Catalan giants in the league since May 2009.
Quique Setien's side have already lost five times in Spain's top flight this season but a record of 18 wins and four draws has brought them 58 points, leaving them two points clear of second-placed Real Madrid.
The Spanish champions have actually won five of their last six league matches, and as mentioned above, have dominated their recent meetings with Mallorca, scoring five times in each of their last two clashes.
Barca still have to travel to Sevilla and welcome Atletico Madrid before the end of the season, but they are in charge of their own destiny and will be determined to put three points on the board this weekend.
The games will come thick and fast for Setien's team as a mid-week clash with Leganes is followed by a trip to Sevilla on June 19, while the club will also be eagerly anticipating an announcement on the Champions League.
Mallorca La Liga form: LLWDLW
Barcelona La Liga form: WWWWLW
Barcelona form (all competitions): WWWDLW
Sevilla should return to a midfield position, while on-loan Real Madrid attacker Takefusa Kubo is likely to feature against the club that he represented for four years before seeking pastures new.
Messi had given Barca a scare by picking up a minor thigh injury last week, but the Argentina international has been declared fit, while the lockdown period has allowed Suarez the chance to recover from knee surgery.
Further back, Clement Lenglet's suspension will open the door for Samuel Umtiti to start, while Sergi Roberto is expected to get the nod at right-back due to the uncertainty surrounding Nelson Semedo's involvement.
Semedo is due to undergo another coronavirus test ahead of the contest, having allegedly broken rules when it comes to large gatherings by attending a birthday party with 19 other people.
Mallorca possible starting lineup:
Reina; Gamez, Raillo, Valjent, Pozo; Kubo, Baba, Sevilla, Rodriguez; Hernandez, Budimir
Barcelona possible starting lineup:
Ter Stegen; Roberto, Pique, Umtiti, Alba; De Jong, Busquets, Vidal; Griezmann, Suarez, Messi
We say: Mallorca 0-2 Barcelona
It is difficult to predict exactly what will occur due to the circumstances surrounding the contest, but Barca will fancy their chances of picking up an important three points. Suarez's expected return is big news for the champions, who should have enough to emerge victorious on the night.