The visitors have already renewed hostilities with Barcelona off the pitch regarding their pursuit of Lionel Messi, and they are now returning to the scene of La Remontada, where Barca overturned a 4-0 deficit to win 6-1 in the 2016-17 Champions League.
Here, Sports Mole looks at how PSG could line up for the contest.
PSG attacker Neymar has talked up the prospect of a reunion with Messi in the French capital, but the Brazil international - who boasts seven goals in this fixture - will not return to Camp Nou this week due to a groin injury, which could rule him out of the second leg as well.
With fellow winger Angel Di Maria also sidelined, Pochettino could once again turn to Moise Kean - who hit double figures for the season against Nice - to fill the void on the right, while Kylian Mbappe will attack down the left.
Julian Draxler has endured a troubled campaign due to injuries, but the Germany international justified his manager's faith in him with the opener against Nice and should line up behind Mauro Icardi, especially with ex-Barca man Rafinha doubtful with a muscular problem.
Marco Verratti is another midfielder who could be forced to miss out due to a hip injury, so Idrissa Gueye and Leandro Paredes are likely to line up in the heart of Pochettino's midfield, but the fit-again Ander Herrera is another option.
Marquinhos's sloppy pass allowed Nice's Rony Lopes to score on Saturday, but the Brazilian is not in any danger of losing his place in defence alongside Presnel Kimpembe, although Alessandro Florenzi could replace Thilo Kehrer at right-back.
Pochettino's number one Keylor Navas returned in between the sticks at the weekend in place of Sergio Rico, and the Costa Rican will somehow attempt to keep his 14th clean sheet of the season at Camp Nou on Tuesday.