No team has lost fewer times than Atletico (1) in Spain's top flight this season, but the capital giants have only won four of their nine matches to sit fifth in the table.
Simeone's side flew out of the traps with three straight wins over Getafe, Leganes and Eibar but suffered a 2-0 defeat at Real Sociedad on September 14 and have struggled to show their best form in the league since.
Indeed, they have actually drawn four of their last five in Spain's top flight, the only exception being a 2-0 win at Mallorca on September 25. Since then, the Madrid side have shared the points with Real Madrid, Real Valladolid and Valencia, and goals have been a real issue for the Red and Whites in recent matches.
The likes of Barcelona and Real Madrid have also had their problems this season, though, meaning that Atletico are only three points off the top of the table as things stand. That said, they are only actually three points ahead of 10th, which is an indication of the type of season it has been thus far.
Simeone's side are going well in the Champions League, though, collecting seven points from their three matches to sit second in Group D, and they will enter this match off the back of a 1-0 win over Bundesliga side Bayer Leverkusen on Tuesday night.
Three wins, four draws and two defeats – that is how Bilbao have performed in La Liga this season, which is not dissimilar to Atletico. Indeed, just three points separate the two teams in the table heading into Saturday's contest.
The Basque outfit recorded a 1-0 victory over Barca on the opening night of the new season before going unbeaten in the league until the end of September, when they suffered a 1-0 loss at home to Valencia.
Gaizka Garitano's side then lost at Celta Vigo one week later, before being held at home by Valladolid last weekend. A run of four without a win has seen them drop down the table, but they would climb a few places should they manage to record a victory at the Wanda Metropolitano on Saturday night.
The omens are not exactly terrific for Bilbao, though, as they have not won a league game away to Atletico since January 2011, losing the last four in the process.
Atletico have also been incredibly strong at home since moving into their new stadium, with Real Madrid the last team to beat them in a league fixture in front of their own supporters, which occurred at the start of February.
Atletico Madrid form: LDWDDD
Athletic Bilbao form: DWDLLD
Simeone's side will also be without Joao Felix as the 19-year-old battles to overcome the ankle issue that he picked up against Valencia last weekend.
Simeone has a problem at the back, though, with Jose Gimenez picking up a thigh injury in the early stages of the clash with Leverkusen. As a result, Hermoso and Felipe are expected to feature as the two centre-backs.
As for Bilbao, Yuri Berchiche and Ibai Gomez are again expected to miss out with shoulder and groin injuries, but the Basque outfit have no fresh injury concerns from the side that drew with Valladolid at the weekend.
Atletico Madrid possible starting lineup: Oblak; Trippier, Felipe, Hermoso, Lodi; Lemar, Koke, Thomas, Saul; Costa, Morata
Athletic Bilbao possible starting lineup: Simon; Capa, Alvarez, I Martinez, Balenziaga; Lopez, D Garcia; Cordoba, R Garcia, Muniain; Williams
We say: Atletico Madrid 1-0 Athletic Bilbao
It is difficult to imagine that this will be an open affair full of goals, Atletico are just not that type of team. Simeone's side are so strong at home, though, and we fancy them to record a narrow win in the capital.
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