Both teams picked up crucial victories on Wednesday, with the hosts thrashing Lorient 5-2 while Angers claimed a shock win at the home of title hopefuls Lille.
Lorient were on course to take a point from their clash with Monaco after a hotly-contested first half, and the two sides could not be separated heading into the break following goals from Axel Disasi and Terem Moffi.
However, Jonathan Delaplace's sending off within three minutes of the restart allowed the floodgates to open, and Monaco took advantage with a flurry of second-half goals to kick off 2021 in perfect fashion.
It has been a long road back for Aleksandr Golovin after a lengthy spell on the sidelines with a hamstring problem, but the Russian playmaker came off the bench to give Monaco the lead within 10 seconds of being introduced - the fastest goal by a substitute in Ligue 1 since October 2007.
Kevin Volland, Sofiane Diop and Guillermo Maripan rounded off the scoring as Niko Kovac's men ultimately recorded a comfortable victory over the strugglers, and only one point separates Monaco from fifth-placed Marseille, although Les Olympiens do have two games in hand.
Monaco's potent attack already boasts 33 goals for the season - a tally which is only bettered by Lyon and Paris Saint-Germain - but Angers are not to be taken lightly and will be determined to stretch Monaco's winless run on home soil to three matches this weekend.
Stephane Moulin has propelled Angers into European contention over the past few weeks, and Saturday's visitors displayed their top-six credentials with a memorable 2-1 win at Lille in their first fixture of 2021.
A first-half brace from an unlikely source in Romain Thomas was enough for Les Scoistes at the Stade Pierre-Mauroy, although Lille did threaten a comeback as Burak Yilmaz netted on the stroke of half time, but Angers held on for another impressive victory.
Moulin's men had beaten Marseille by the same scoreline in their farewell to 2020, and with a respectable record of four wins from their last seven in Ligue 1, Angers are firmly in the conversation for a spot in the Europa League.
Les Scoistes and their opponents Monaco boast an identical record of nine wins, three draws and six losses from their opening 18 matches, but Angers are notoriously strong on the road - only Lyon boast a better record on unfamiliar territory this season - and Moulin's men will be aiming to stretch their unbeaten away record to seven matches this weekend.
A Stevan Jovetic header was enough for Monaco to prevail in this fixture last season, and Angers have only picked up a solitary win from their last eight matches with Les Monegasques.
Monaco Ligue 1 form: LLLWDW
Angers Ligue 1 form: WDLDWW
Monaco will welcome Eliot Matazo back from suspension for this tie, but it is difficult to see the 18-year-old forcing his way into the starting lineup here.
Kovac may not want to risk Golovin from the first whistle just yet despite his immediate impact in midweek, but Diop and Maripan also came off the bench to score on Wednesday and could be rewarded with starting roles here.
Indeed, it would be a surprise to see any member of the visitors' starting XI drop out after their win at Lille, although Stephane Bahoken could be in line for a recall up top.
Monaco possible starting lineup:
Lecomte; Aguilar, Maripan, Badiashile, Henrique; Martins, Fofana, Tchouameni, Diop; Ben Yedder, Volland
Angers possible starting lineup:
Bernardoni; Bamba, Thomas, Traore, Manceau; Mangani, Coulibaly; Capelle, Fulgini, Lage; Bahoken
We say: Monaco 2-2 Angers
Angers showed no signs of trepidation against Marseille or Lille, and a third successive fixture against a fellow European hopeful is sure to be a true test of their mettle. Monaco cannot afford to underestimate the high-flying visitors, and the scoreline in their clash with Lorient could have been wholly different had Les Merlus not gone down to 10, so we can see Angers extending their unbeaten away streak with a closely-fought draw this weekend.