De Villiers has admitted that England's reliance on Tim Bresnan's batting at seven could be something they target in the series.
The batsman said: "I think they are a little bit light in the batting department - that might be something that we will be attacking. We'll see.
"They've got Bresnan that I think they rely on quite a bit coming in at seven. The reason why they're playing conservatively up front is because they're a batter light. They don't go with the wicketkeeper at seven like most teams do."
Albie Morkel is the only major fitness concern for South Africa ahead of Friday's game in Wales.