The tourists managed to pass 300 for the first time on their tour of England as they closed the day on 327 for seven.
Sehwag was making his first appearance since recovering from injury but he was out for eight as he fell to Northamptonshire's fast bowler Dave Burton.
Burton, who is making only his sixth first-class appearance, believes that the manner of Sehwag's dismissal could help England.
"There is now footage for England to see, watch the whole spell, and see if swinging deliveries are going to get him," said Burton.
"I've watched him many times. [Sachin] Tendulkar, [Mahendra Singh] Dhoni, Sehwag, I've grown up watching them.
"The one with which I got his wicket kept straight and was still going straight and his front foot was stuck in the crease when it hit him."
India are 2-0 down to England ahead of the third Test at Edgbaston on Wednesday, August 10.