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Centurion Steve Smith (111) was the next to go after a review, although he seemed unhappy after Hotspot and Snicko could only pick up the faintest of inside edges on its way through to Prior.
The tourists thought that they had Ryan Harris when Ian Bell took a clean catch at gully, but umpire Billy Bowden's original decision was proven correct after Alastair Cook chose to use another review.
Replays showed that the ball had deflected off the tailender's thigh pad, but he was eventually sent back with 12 runs to his name when James Anderson found a thick edge and Joe Root scooped at gully.
Tim Bresnan wrapped it up with his first wicket, as he tempted Siddle (21) to play outside off-stump and edge behind for Prior to take the catch, leaving Lyon as the last man standing on 17.