Maidana stunned the boxing world by beating Adrien Broner in his last bout in December, but after coming through 45 contests without defeat, Mayweather doesn't believe that the Argentine can crack the "MayVinci Code".
The 37-year-old told reporters: "The gameplan is to stay in the pocket. Make the guy miss and make the guy pay.
"Is Marcos Maidana one of the best in the sport? Absolutely. But I am the best there is. We are still wondering who's going to solve the 'MayVinci Code'? But come Saturday, I will find a way to win."
Read about the the main event and undercard in Las Vegas in Sports Mole's preview.