Mayweather is undefeated in 43 bouts and is the heavy favourite to beat Guerrero, and the five-weight world champion has revealed that he feels "unbeatable" ahead of the WBC welterweight fight in Las Vegas.
The 36-year-old told a press conference: "I feel unbeatable. I'm not going into a fight thinking I'm beatable.
"My main focus is to win. I'm always going to control the tempo of any fight because of my experience."
Opponent Guerrero has suffered just one defeat in 35 professional bouts.