Harden stole the show at the Quicken Loans Arena, having notched 37 points, 11 assists and four steals in order to hand the Rockets a win away from home.
"I just tried to be aggressive and be in attack mode to get to the rim," Harden told reporters after the encounter.
"If the shot is there, I take it. If the pass is there, I make sure I make the right pass every time.
"It's just a matter of me using my basketball instincts."
The win sees the Rockets occupying second position in the Southwest Division with a record of 47-22 for the season.