The Giants trailed the Philadelphia Eagles by just one point in the final quarter before Manning threw three interceptions to allow the opposition to clinch a 36-21 victory and condemn his side to a fifth straight defeat.
Coughlin put much of the blame for the defeat on Manning after the match, but believes that the 32-year-old will be able to bounce back in time for Thursday's game against the Chicago Bears.
"We did visit today, and he feels bad about the game, just as we all do. We're suffering remorse from opportunity lost," Coughlin said on a conference call with reporters.
"But he's certainly going to get right back up again in preparation, very short preparation, for the next opponent. And I know that part will be done properly. And I wish I could bring his spirits back up, but unfortunately it's still very close to yesterday."
Meanwhile, Manning has claimed that he is not playing "lousy" football despite the Giants' poor start to the NFL season and the fact that he leads the league in interceptions with 12.