The AFC East leaders will be without Vince Wilfork, Jerod Mayo and Sebastian Vollmer for the rest of the year, while cornerback Aqib Talib could also miss this weekend's game against the Pittsburgh Steelers.
The Steelers quarterback told reporters: "No, I mean it's still a good defense, they still make plays. Those guys are obviously, you get Vince in the run game and Jerod in both, he had been playing lights-out football.
"Those are marquee guys for them, but in typical New England fashion they fit guys in and find ways to get it done.
"[Talib is] a very good player, very ball-aware and someone that when you're playing against him you have to know where he's at and what he's doing."
The Patriots host the Steelers on Sunday.