The New England Patriots signed off their pre-season campaign with a defeat at the hands of the New York Giants.
Both sides rested their starters for the majority of the contest, and Giants' backup Ryan Nassib led his side to victory as Chris Boswell kicked four field goals although the visitors were made to make a stand in the endzone as Damontre Moore picked off Ryan Lindley to secure the 12-9 win.
Tom Obarksi kicked a late field goal to hand the Bengals the 9-6 victory after the clubs had cancelled each other out for the majority of the match despite previous kicks from Mike Nugent and Adam Vinatieri.
Collin Mooney put the hosts ahead and a touchdown pass from Sean Renfree extended their advantage. John Harbaugh's men tried to come back in the fourth quarter, but two touchdown strikes from Byrn Renner were not enough for the home team.
The Bills took the lead when Ron Brooks returned an interception 80 yards for a touchdown, but the Lions fought back through a strike from Kellen Moore to TJ Jones and a run from Zach Zenner secured the victory.
The Carolina Panthers hammered the Pittsburgh Steelers 23-6 to finish 3-1 in their pre-season campaign.
Rashad Ross's score was cancelled out by the Jaguars' Corey Grant, and the home side went ahead through Bryan Walters only for Mack Brown to tie the score with a run. However, Myers decided the contest with a kick from 47 yards in the fourth quarter.
Titans quarterbacks Marcus Mariota, Zach Mettenberger and Alex Tanney all threw one touchdown each to guide their side to the win, despite a two-score display from Vikings signal-caller Taylor Heinicke.
A score from Spencer Ware and touchdown strikes from Chase Daniel and Aaron Murray were enough to clinch the victory, despite a rushing score from Isaiah Pead and an interception return from Cody Davis.
David Fales threw two touchdown passes to Marc Mariani and Ify Umodu, while Sherrod Martin returned an interception for a 25-yard touchdown to seal an emphatic win.
Dylan Thompson fired a 70-yard touchdown pass to Bruce Ellington and the hosts made the two-point conversion, but Richard Crawford responded with an interception return for a touchdown.
The conversion proved to be the difference between the sides as a second-half score from Rory Anderson was cancelled out by Tyrell Willliams, but the 49ers held out for the win.
Pre-season results in-full: New York Giants 12-9 New England Patriots, Cincinnati Bengals 9-6 Indianapolis Colts, Philadelphia Eagles 18-24 New York Jets, New Orleans Saints 10-38 Green Bay Packers, Tampa Bay Buccaneers 22-17 Miami Dolphins, Baltimore Ravens 19-20 Atlanta Falcons, Buffalo Bills 10-17 Detroit Lions, Carolina Panthers 23-6 Pittsburgh Steelers, Jacksonville Jaguars 17-16 Washington Redskins, Minnesota Vikings 17-24 Tennessee Titans, Kansas City Chiefs 24-17 St Louis Rams, Houston Texans 14-21 Dallas Cowboys, Cleveland Browns 0-24 Chicago Bears, Arizona Cardinals 22-20 Denver Broncos, San Diego Chargers 12-14 San Francisco 49ers, Oakland Raiders 21-31 Seattle Seahawks