Peyton Manning broke the NFL record for most career touchdown passes and guided the Denver Broncos to their fifth win of the season as they hammered the San Francisco 49ers 42-17 in their clash at Sports Authority Field.
The 38-year-old got his side on the scoreboard in their first drive of the game when he fired to Emmanuel Sanders over the middle of the endzone for a three-yard score.
Manning spread the ball out well to his receivers and notched his second strike of the game when he looped a pass to Wes Welker, who sprinted and then dived to the pylon for a 39-yard touchdown.
In the second half, a costly mistake by Kaepernick put the Broncos in prime position to extend their lead as his pass was picked off by Aqib Talib. Manning took full advantage as he fired deep to Thomas for a 40-yard touchdown.
Late in the third quarter, Hillman put the game beyond doubt after Manning moved his side to the goal line with another excellent series of throws, and that allowed the back to power over for the score.
The 38-year-old was pulled from the game in the fourth quarter with the result beyond doubt at 42-10. The 49ers managed to get a consolation touchdown when backup Blaine Gabbert fired to Bruce Ellington for a walk-in touchdown, but the night belonged to the Broncos and Manning.