Buffalo Bills head coach Rex Ryan aims to make life "miserable" for Andrew Luck

Buffalo Bills head coach Rex Ryan has outlined his ambition to make life "miserable" for Indianapolis Colts quarterback Andrew Luck in their season opener.

The Colts reached the AFC championship game last season due to the performances of Luck, who notched 40 touchdowns in the regular campaign.

Ryan has admitted that his side have to make it as difficult as possible for the 25-year-old to secure a victory over the AFC South side.

He told reporters: "We have to make it miserable when people come in here. I'm calling our fans out. We need you. This guy is the number one fantasy quarterback for this week. He's the play.

"He's the go-to-guy. Everybody wants him. But we have to make it challenging for him, and we will with our defense and all that.

"We're going to make it as challenging as we possible, can but it can only be added by our fans. When our defense is on the field, I can't wait to see our fans."

The Bills face off against the Colts at Ralph Wilson Stadium on Sunday.