Harbaugh met the US President at the White House in June when the team were honoured as the 2012 Super Bowl champions, and he wished them luck for the upcoming campaign.
According to Baltimore Ravens.com Obama told Harbaugh: "Best of luck next season – you're going to need it in week 11 when you go to my hometown of Chicago to play the Bears."
Ahead of the the Ravens trip this weekend, Harbaugh was reminded of the comment.
He said: "Thank you for that reminder. We appreciate the President and the fact that he's a huge football fan and sports fan. I'm sure he'll be watching this game very closely, and we'll do our best to disappoint him."
The Ravens have a 4-5 record so far this season and sit in third place in the AFC North.