Mathieu must undergo surgery after he sustained a double anterior cruciate and lateral collateral ligament injury during Sunday's win over the St Louis Rams.
He told reporters: "I've never been injured before, and to have my first injury be so severe I am sure it will take its toll on me as the months count down.
"I've been through enough already. Hopefully this can add some motivation into my life and let me reflect even more, grow closer to God and those type of things."
The Cardinals currently sit in third spot in the NFC West.