Both players struggled to come to terms with the conditions in the early stages, but the match remained on serve in the opening four games.
Simon took advantage of a poor service game from Lopez to break moments later, but Lopez broke straight back as the first set headed for a tie-break.
Lopez continued to dominate from the baseline, however, with the Spaniard claiming the tie-break 7-2 to open up a one-set lead in Eastbourne.
Both continued to serve well in the second, with the set once more heading for a tie-break as the windy conditions eased somewhat.
It was Simon who came out on top, the Frenchman sending the final into a third set.
Lopez dominated from the onset, however, as the Spaniard claimed the third set with a comfortable 6-0 score.