Following Andy Murray's shock exit on Wednesday, Queen's Club saw another top seed leave the tournament on Thursday as Jo-Wilfried Tsonga was defeated by Ivan Dodig in three sets.
The Croatian took out the number two seed 7-6 3-6 7-5 to set up a quarter-final encounter with Sam Querrey following the American's triumph over Julien Benneteau.
Murray's conqueror Nicolas Mahut is now out of the competition after he was beaten in two by Bulgaria's Grigor Dimitrov.
Dimitrov will face Kevin Anderson in the last eight thanks to the South African's straight-sets victory over Feliciano Lopez.
Xavier Malisse's reward for knocking out Simone Bolelli is a match with either David Nalbandian or Edouard Roger-Vasselin, while Marin Cilic will play the winner of Janko Tipsarevic's rained-off clash with Yen-Hsun Lu.
