The Spaniard was outplayed in London as Nishikori advanced to the the quarter-finals.
However, Ferrer - the fifth seed in Melbourne - believes that the change of surface will alter the scope of the match entirely.
"It's going to be a very physical match," said Ferrer. "He has great shots. Power in all his shots.
"He beat me at Olympics, but every match is different. That was on a grass court, in another tournament. I am confident I will have the will to fight."
Ferrer's best performance at the Australian Open came in 2011, when he reached the semi-finals.