The visiting Dons will feel aggrieved to be playing this fixture, have led for a long time in the first match at Stadium MK, only for Heidar Helguson to score a stoppage-time equaliser for QPR.
Hughes will have to make do without the services of captain Joey Barton, who is serving the final game of his three-match suspension. Fellow central-midfielder Alejandro Faurlin will also be absent with a knee injury.
The winner of this tie will host Chelsea.
MK Dons: WLWDWD
QPR: Kenny; Young, Ferdinand, Hill, Traore; Wright-Phillips, Derry, Taarabt, Mackie; Helguson, Campbell.
MK Dons: Martin; Smith, Kouo-Doumbe, Williams, Lewington; Potter, Gleeson; Powell, Chadwick, Bowditch; Ibehre.
Sports Mole says: 2-0