Kalou has been struggling with a thigh injury of late and the Ivorian has been deemed unfit to even make the bench.
Franck Djadjede and Alexy Bosetti will lead the attack for Nice, who will have Kevin Anin, Didier Digard, Eric Bautheac and Mahamane Traore in midfield.
Joris Delle will be in goal for the home side.
Nice:Delle, Pejcinovic, Civelli, Kolodzieczak, Palun, Anin, Digard, Bautheac, Traore, Djadjede, Bosetti
Lille: Landreau, Sidibe, Rozehnal, Bonnart, Beria, Gueye, Pedretti, Balmont, Bruno, Roux, Payet