A Napoli win would move them three points behind Juventus while a victory for the Turin giants would see them stretch their lead to nine points.
Prandelli said, however, that whichever team emerges victorious will go on to claim the scudetto.
"The game will give you the exact destination of the title," Gazzetta dello Sport quotes Prandelli as saying.
"It is a game that will be full of emotion and technical ability. They are two very large clubs and we hope to see a great match.
"Both coaches have built their careers on very hard work, and the match should reflect this."
Napoli have lost just once at Stadio San Paolo all season.