The rookie quarterbacks faced each other twice during their college careers, each claiming one victory.
The Bills quarterback told reporters: "I'm looking forward to getting down there and playing against Mike. He's been doing well, so I look forward to going out and have a good game.
"I think we have a lot more similarities than people think. We both throw the ball well, and try to stretch it vertically, and do different things like that."
Manuel, who was the only quarterback selected in the first round of this year's Draft, won the starting job with the Bills in pre-season, while Glennon has started eight games after replacing Josh Freeman earlier in the campaign.