Johnson has recorded 1,000-yard receiving seasons in his past three years in the NFL and feels that no player on the Patriots' roster will be able to stop him on Sunday.
Johnson told ESPN: "I don't think they have anybody to stop me — for real. I think we have guys in the receiver room that are as good as I am, if not better.
"I just have that confidence in my teammates and in myself. I give a lot of credit to the Patriots. They play as one unit. They're aggressive.
"It's going to be a test. It's going to be a challenge. But I still think we can take advantage of their defense. I'll still ride with my boys over their guys."
Undrafted rookie Jeff Tuel is poised to start for the Bills at quarterback in the absence of EJ Manuel and Kevin Kolb against New England.