Murray confirmed at the start of the month that he would be working with the two-time Grand Slam winner "initially for the grass-court season".
Despite widespread praise for Murray hiring a female coach, Wade has big doubts about the partnership working.
"It's hard to read him. Mauresmo was a total shock, I thought they were all fooling around. I think again he's maybe trying to mess with everybody. I don't know," she is quoted as saying by Sky Sports News.
"She's laid back, she's a very nice, mature person, but I can't work it out at all. You like to try to get behind people's thinking but I can't really with this one. You try to see what somebody's going to offer that player."
Murray will start the defence of his Wimbledon title next week when he faces David Goffin in the first round at the All England Lawn Tennis Club.