The fourth seed looked to be cruising in the early stages as he wrapped up the first set in just 25 minutes without losing a single game.
Smyczek battled back from 0-3 down to make a fight of the second set, finally finding a way to make his mark on the match before being edged out 7-5 by the experienced Spaniard.
Ferrer was caught napping at the end of the third as Smyczek's persistence finally earned the American a breakthrough as he avoided a straight-sets defeat with some powerful baseline returns.
Dropping a set visibly angered Ferrer as he stepped up the intensity in the fourth to close out what had become a tricky encounter to negotiate.
Smyczek went for broke on the Spaniard's serve but could not find a way to level the match as Ferrer finally progressed in four sets despite squandering three match points.