"It's great to name an unchanged starting XV, the players deserve that for a very good performance on the opening weekend," Gatland is quoted by BBC Sport as saying.
"We have made one change on the bench, with George coming in for Owen (Watkin), which is tough on Owen but Josh (Adams) picked up a slight strain last weekend so George provides us a bit more cover there.
"We know how tough it is going to be against that huge English forward pack. They are really going to test us.
"England have been in great form the last couple of years so we know the challenge we face but we have had a good couple of weeks in camp and we are looking forward to going up to Twickenham."
Wales starting XV: Halfpenny (Scarlets); Adams (Worcester), S Williams (Scarlets), Parkes (Scarlets), S Evans (Scarlets); Patchell (Scarlets), G Davies (Scarlets); R Evans (Scarlets), Owens (Scarlets), Lee (Scarlets), Hill (Dragons), AW Jones (Ospreys capt), Shingler (Scarlets), Navidi (Cardiff Blues), Moriarty (Gloucester)
Wales replacements: Dee (Dragons), W Jones (Scarlets), Francis (Exeter Chiefs), B Davies (Ospreys), Tipuric (Ospreys), A Davies (Scarlets), Anscombe (Cardiff Blues), North (Northampton)