Wales forwards Alun-Wyn Jones and Josh Turnbull have both been ruled out of the remaining Autumn Internationals with shoulder and knee injuries respectively.
Jones injured his shoulder during Wales's meeting with Argentina last weekend and scans revealed that he will not be fit to take part for the remainder of the year.
Meanwhile, Turnbull suffered medial ligament damage to his knee at the weekend and will miss at least four weeks with the injury.
Neither player will be fit to face Samoa, New Zealand or Australia, but no additional call-ups have been made.