Toulon opened the scoring through a Jonny Wilkinson penalty, but Montpellier soon took control of the match, preventing the visitors from adding further to their score.
A try and three penalties gave the hosts a comfortable lead at half time, helped by Toulon being reduced the 14 men for a time when Delon Armitage was sin-binned.
Benoit Paillaugue added a try early in the second half to effectively seal the game for Montpellier, with Toulon offering little in the way of attack.
As the game went on, the hosts substituted a number of their starters, allowing their fringe players some time on the field.
Toulon have won all five of their previous games during the pool stage of the competition.body check tags ::