Anything but a heavy defeat will ensure that the Tigers play at Welford Road in next week's semi-finals.
Meanwhile, George Skivington will captain the Exiles, who have the poorest away record in the league this season.
Leicester: Murphy, Morris, Tuilagi, Allen, Goneva, Flood, B Youngs, Mulipola, T Youngs, Catrogiovanni, Kitchener, Parling, Croft, Salvi, Crane
Irish: Homer, Ojo, Joseph, Armitage, Yarde, Humphreys, Allinson, Corbisiero, Lawson, Aulika, Skivington, Evans, Garvey, Gibson, Treviranus
Sports Mole says: A comfortable win for Leicester Tigers