Ireland have named a revamped front row of Dave Kilcoyne, Ronan Kelleher and Tadhg Furlong as part of seven personnel changes for Saturday's Guinness Six Nations clash with Italy.
Skipper Johnny Sexton and vice-captain James Ryan will return from head injuries in Rome but Conor Murray remains absent due to a hamstring injury, meaning Jamison Gibson-Park will continue at scrum-half.
Ryan's recall alongside Iain Henderson in the second row has resulted in Tadhg Beirne switching to blindside flanker in place of Rhys Ruddock, with Will Connors taking over from Josh Van Der Flier at openside.
Ireland have made their worst start to a Six Nations campaign and will be seeking to bounce back from defeats to Wales and France at Stadio Olimpico.
Leinster hooker Kelleher has been rewarded for his try-scoring cameo in the 15-13 defeat to Les Bleus on February 14 with a first Championship start.
Loosehead prop Kilcoyne has won 32 of his 40 caps as a replacement and will start a Test for the first time since the 2019 World Cup pool stage, while tighthead Furlong will begin an international match for the first time in a year.
Influential Leinster duo Sexton and Ryan make welcome returns after being forced to sit out the France game having suffered head knocks on the opening weekend in Cardiff.
Opponents Italy, who last beat Ireland in March 2013, will be bidding to avoid a 30th successive Six Nations defeat.