The Harlequins scrum-half has been criticised for his performances in England's defeats to New Zealand and South Africa over the last fortnight.
Stuart Lancaster has also dropped Billy Vunipola and Kyle Eastmond to make space for James Haskell, Billy Twelvetrees, and Richard Wigglesworth in his 23-man party, while Luther Burrell and Calum Clark return to their clubs.
Leicester Tigers number nine Ben Youngs and Twelvetrees are being tipped for starts at Twickenham.
Forwards: Attwood, Brookes, Hartley, Haskell, Kruis, Lawes, Marler, Morgan, Mullan, Robshaw (captain), Webber, Wilson, Wood.
Backs: Barritt, Brown, Farrell, Ford, May, Twelvetrees, Watson, Wigglesworth, Yarde, Youngs