The 34-year-old, despite being left out of the series-deciding final Test, was part of the British and Irish Lions side that successfully toured down under during the course of the summer, and they find themselves clashing again at the weekend in Dublin.
"He's got a real street smartness of how he goes about it," McKenzie said in a press conference. "He's got a lot of tricks out there.
"It's going to be a real challenge for us because whoever is going to be in front of him is probably only going to have a handful of Tests under his belt. Whoever we play, it's going to be a little bit daunting for our guys but a good challenge."
O'Driscoll will win his 135th cap during the game.