A Mehdi Taremi brace saw Vitoria de Guimaraes narrowly lose out to Porto despite pushing them all the way, while the visitors ended a three-game losing streak with a 2-0 win against Tondela courtesy of strikes from Ruben Micael and Brayan Riascos.
Teams generally tend to perform better at home compared to away but Vitoria de Guimaraes' case so far has been an exception.
Only the league leaders Sporting Lisbon have a better away record than Os Conquistadores but surprisingly, only four teams have picked up fewer points than them at home.
They currently sit fifth but Joao Henriques will know that his team could go even higher provided they start doing better at home, and improving their poor return of four goals in six games would be an ideal starting point.
Following exits from both domestic cups earlier in the month, Vitoria de Guimaraes can now pay full attention to the league where securing European football for next season will be the target.
Nacional have enjoyed a decent start to life back in the top flight since their promotion from the Segunda Liga where they were champions.
Luis Freire's men could cut the gap between them and their hosts to three points should they manage a victory.
Key to their form has been Brayan Riascos, who has continued his goalscoring exploits from last season and currently leads the way for the Alvinegros having scored four goals this term.
However, a victory would take some doing considering the fact that they only rank 14th in terms of away points picked up so far.
Vitoria de Guimaraes Primeira Liga form: LWWWLW
Vitoria de Guimaraes form (all competitions): LWLLWW
Nacional Primeira Liga form: WLLLWD
Nacional form (all competitions): WLLLWW
Joseph Amoah and Matheus Mascarenhas are both out with knee and muscle injuries respectively while Yann Bisseck still awaits his debut due to a muscle tear that has kept him out since his loan move from Koln.
Jorge Fernandes came off with an injury in the defeat to Porto but he should be available for Sunday's game.
Nacional have everybody fit for this one but some changes could be made from the team that won against Tondela last time out.
Vitoria de Guimaraes possible starting lineup:
Varela; Mensah, Mumin, Fernandes, Sacko; Andre, Pepelu, Almeida; Quaresma, Estupinan, Rochincha
Nacional possible starting lineup:
Daniel; Vigario, Kal, Cesar, Freitas; Nuno, Riascos, Azouni, Ramos, Camacho; Gorre
We say: Vitoria de Guimaraes 2-0 Nacional
Vitoria will look to return to winning ways and should get the job done given the gulf in quality all over the pitch between both teams.