The hosts will be aiming to kick-start their season as they find themselves 10th in the A-League table after a disappointing run of one win in five matches.
Western United will be looking to get up and running when they return to Geelong on Saturday, after a poor start to the 2020-21 A-League campaign.
Mark Rudan's men have picked up just five points from a possible 15 and are currently seated 10th in the league table with two draws and two defeats.
In a disappointing performance, the hosts blew the lead twice to fall to a 3-2 defeat against Central Coast Mariners last time out.
On the other hand, the visitors continue their push for a third-straight A-League success after an impressive start to the new campaign.
After a 2-1 victory over Wellington in their league opener, the Sky Blues stumbled to a draw against Western Sydney Wanderers before suffering a 2-0 defeat to Central Coast Mariners
However, Steve Corica's men quickly bounced back from the defeat to the league leaders to grab back-to-back victories against Macarthur and Wellington Phoenix.
In the clash against Wellington last time out, a brace from New Zealand international Kosta Barbarouses inspired Sydney to a 2-1 victory which saw them move up to fifth in the league table.
Western United and Sydney have only ever met twice, when both sides shared the spoils with a win each in the two meetings last season.
Two first-half goals from Adam Le Fondre gifted the visitors a 2-0 win in the first fixture, while Rudan's men grabbed a 2-1 victory at the Leichhardt Oval Stadium in the most recent meeting.
This is the fifth time Rudan and Corica will be going head to head in their coaching careers, with the latter having a slight advantage after picking up three victories compared to Rudan's two.
Western United have a decent record on home turf this season as they are unbeaten with one win and two draws, while Sydney have won both of their away games so far.
Western United Australian A-League form: LDWLD
Sydney FC Australian A-League form: WWLDW
Western United will be boosted by the return of Max Burgess, who is expected to make the starting XI following an extended holiday.
Sydney, meanwhile, have a relatively long injury list coming into this fixture.
Australian-born midfielder Chris Zuvela is a doubt after picking up an injury last time out, while goalkeeper Adam Pavlesic remains on the sidelines after a heavy knock in the AFC Champions League back in December.
Western United possible starting lineup:
Kurto; Calver, Durante, Vujica; Uskok, Sanchez, Lustica, Imai; Burgess, Diamanti, Berisha
Sydney FC possible starting lineup:
Redmayne; King, Warland, Wilkinson, Grant; Brattan, Baumjohann, Ninkovic, Caceres; Barbarouses, Buhagiar
We say: Western United 1-3 Sydney FC
Western United have failed to get into gear this season, and they face a Sydney side who appear to have found their rhythm.
The defending champions have been faultless away from home and, considering they have a stronger squad, they should grab all three points unscathed.