To keep a fearsome Italian team at bay on Wednesday, the Swiss will rely on their gritty midfield unit - including captain Granit Xhaka and Atalanta's Remo Freuler - plus a back three of Bundesliga pair Manuel Akanji and Nico Elvedi alongside Newcastle United defender Fabian Schar.
Upon his return to Stadio Olimpico, former Lazio coach Vladimir Petkovic could name a lineup unaltered from the opening game with Wales.
Most likely to break into the side is Denis Zakaria, who featured as a substitute last time out in Baku, with either Freuler making way or one of Switzerland's two strikers dropping out to cater for an extra body in midfield - an area where Italy excel.
Back-up goalkeeper Jonas Omlin, meanwhile, has been removed from La Nati's 26-man squad, after suffering an ankle injury while warming up on Saturday, so uncapped Gregor Kobel will replace him on the bench.
At the other end, striker Mario Gavranovic was a lively second-half presence versus Wales - and previously netted a hat-trick in the 7-0 win over Liechtenstein in Switzerland's final warm-up game - so could possibly usurp Haris Seferovic in the front two. Pacy and energetic, Breel Embolo is set to keep his place; providing a direct threat to Italy's formidable but ageing back line.
Switzerland possible starting lineup: Sommer; Elvedi, Akanji, Schar; Mbabu, Xhaka, Freuler, Rodriguez; Shaqiri; Embolo, Seferovic