The Saints will be looking to build on a domestic cup double and a fifth-place finish achieved last season, while the hosts will be hoping they can avoid another relegation battle this time around.
Ross County will be playing Premiership football once again this year after winning their final three league games of last season, which helped them to move three points clear of the bottom two and avoid relegation.
The 49-year-old – who was investigated by the FA in 2014 for sending allegedly racist, sexist and homophobic text messages to Cardiff's head of recruitment Iain Moody – has received a backlash amid supporters concerns regarding his appointment. Mackay, however, insists that he has learnt from his past mistakes and believes he has "unfinished business" as a manager.
Ross County's preparations for the 2021-22 season have been derailed due to an outbreak of coronavirus within their camp, which forced the Staggies to forfeit their first two League Cup games against Forfar and Dundee.
Since then, they beat Brora Rangers 1-0 on the road before cruising to a 4-1 victory at home to Montrose last weekend, though their late push for a place in the second round was too late as they finished third in Group C behind the two teams they forfeited matches against, Forfar and Dundee.
Ross County have failed to win any of their last eight home meetings against St Johnstone, but a victory on Saturday would be a great way to kickstart their campaign and for Mackay to get the fans onside.
After a hugely successful 2020-21 campaign, St Johnstone are in high spirits and their fans are full of optimism for what lies ahead this year.
The Perth-based outfit are still basking in the afterglow of winning both the League Cup and Scottish Cup, as well as finishing fifth in the Premiership.
Callum Davidson, who was pipped to the SPFL Manager of the Year award by Rangers boss Steven Gerrard, was delighted with how his young, cohesive squad was able to achieve so much last season, and will now be hoping that they can make the next step when they venture into Europe for the first time in four years.
The Saints have been drawn against Turkish giants Galatasaray in a third-round qualifier for the Europa League. Davidson is sure to have one eye on the first leg in Istanbul on Thursday, but he and his side must firstly turn their attention to their opening Premiership game.
Prior to beating Ross County 1-0 in their last meeting in March, St Johnstone had failed to win seven consecutive encounters against them, drawing five times in the process. Heading into Saturday's game, the Saints have also drawn three of their four pre-season friendlies against Preston North End, Aberdeen and Fleetwood Town.
Only Dundee United (14) drew on more occasions than St Johnstone (12) in the top-flight last season, but if Davidson can turn those one-pointers into victories, starting with a win on Saturday, then his side should have a great chance of pushing for a place in the top three, something that the club last achieved back in 2012-13.
Ross County boss Mackay is unlikely to make too many changes from the sides that started against Brora Rangers and Montrose, which would therefore see him stick with a 3-5-2 formation.
Striker Dominic Samuel and left-back Jake Vokins, who also joined the club this summer, will be hoping to make their Premiership debuts and could keep their places in the first XI, after starting the last game against Montrose.
As for St Johnstone, they have had a quiet summer in the transfer window, recruiting defensive trio James Brown as well as Hayden Muller and Reece Devine (both on loan) from Millwall and Manchester United respectively, however, they are not expected to feature in the starting lineup on Saturday.
Ross County possible starting lineup:
Laidlaw; Watson, Donaldson, Iacovitti; Spittal, Paton, Callachan, Tillson, Vokins; Samuel, White
St Johnstone possible starting lineup:
Clark, McCart, Kerr, Gordon; Rooney, Wotherspoon, McCann, Davidson, Booth; O'Halloran; May
We say: Ross County 1-2 St Johnstone
St Johnstone have scored in each of their last eight visits to Victoria Park, though their last four trips have all ended as draws.
Davidson's side will, however, believe they have what it takes to claim all three points this time around, and a narrow victory could be on the cards on Saturday, which would provide the perfect confidence boost heading into next week's Europa League clash.