The Lilywhites finish their top-flight campaign with a home match against Everton, but before then is Saturday's trip to Bournemouth.
Spurs have lost four of their last five matches in all competitions, including a 1-0 defeat to Ajax in the first leg of their Champions League semi-final tie.
This visit to the Vitality Stadium comes four days before Tottenham take on Ajax in Amsterdam in the return fixture, so Mauricio Pochettino must weigh up whether to rotate his squad.
Ahead of Saturday's match, Sports Mole looks at how Spurs may line up.
Tottenham remain without Kane and Winks, while Vertonghen will sit this one out as a result of the concussion suffered against Ajax and Aurier will almost definitely miss out with a hamstring injury.
Son Heung-min is eligible for Saturday's match after sitting out the first leg against Ajax through suspension, and the versatile South Korean forward - who has scored five goals in his last four Premier League games against Bournemouth - seems certain to start.
Pochettino has options in attack, with Vincent Janssen back in the mix following his first appearance for the club in two years last weekend. Fernando Llorente is the other alternative, though the hosts could use Son through the middle.
That decision will likely depend on how Pochettino plans to set up his side for the away trip to Ajax next weekend.
One or more of Dele Alli, Christian Eriksen or Lucas Moura should be given a breather, while at the back the full-backs are expected to be rotated, with Juan Foyth able to slot in on the right if he is not needed centrally.