The Lilywhites have defeated West Ham United, Wolverhampton Wanderers and PSV Eindhoven in three different competitions over the past week to get their campaign back on track.
Spurs boast an impressive record in this fixture, winning six in a row against Palace, and they have also picked up all three points in their last five top-flight London derbies.
Ahead of this weekend's clash in South London, Sports Mole looks at how Tottenham could line up.
Mauricio Pochettino was left light in defensive midfield for the 2-1 win against PSV in midweek due to the injury absence of Dembele, Dier and Wanyama, all three of whom are unlikely to feature again before the international break.
Kieran Trippier and Erik Lamela are among those pushing for recalls after being left out for that much-needed win, with Serge Aurier and Dele Alli - still working his way back to full fitness - potentially making way.
Lamela's inclusion would allow Lucas Moura to move into a central attacking midfield role just off Harry Kane, who has scored 24 goals in Premier League London derbies, bettered only by Teddy Sheringham (32) in Tottenham colours.