Ben Davies is deployed on the left of a back three tonight, with Jan Vertonghen suspended, while Davinson Sanchez and Toby Alderweireld keep their places and skipper Hugo Lloris is present between the posts.
For the hosts, meanwhile, Giorgos Donis makes four changes following the goalless draw at Aris last Friday, playing in an expected 4-3-2-1 formation.
Igor de Camargo leads the line with support from Ghayas Zahid and Efstathios Aloneftis, while Vinicius and Roland Sallai join Nuno Morais in the midfield as Agustin Farias drops to the bench and Lorenzo Ebicilio misses out with a calf injury.
APOEL: Waterman; Vourous, Rueda, Carlao, Roberto Lago; Morais, Sallai, Vinicius; Zahid, Aloneftis; De Camargo
Subs: Gudino, Alexandrou, Merkis, Farias, Makris, Pote, Antoniou
Tottenham Hotspur: Lloris; Alderweireld, Sanchez, Davies; Trippier, Dier, Winks, Aurier; Sissoko, Son; Kane
Subs: Vorm, Foyth, Walker-Peters, Oakley-Boothe, Georgiou, Nkoudou, Llorente
Keep up with all of the action from Cyprus this evening with Sports Mole's live text commentary here.