As for Burnley, Joe Hart made his debut for the club in the Europa League on Thursday night, and the England international keeps his spot between the sticks for this match.
Fellow new arrival Ben Gibson is again on the bench as James Tarkowski and Ben Mee start as the two centre-backs, while Chris Wood returns at centre-forward having missed the goalless draw with Istanbul Basaksehir due to an infected insect bite.
Southampton: McCarthy; Cedric, Stephens, Vestergaard, Hoedt, Bertrand; Romeu, Lemina, Armstrong; Redmond, Austin
Subs: Gunn, Bednarek, Højbjerg, Ward-Prowse, Elyounoussi, Ings, Gabbiadini
Burnley: Hart; Lowton, Tarkowski, Mee, Ward; Lennon, Cork, Hendrick, Westwood, Gudmundsson; Wood
Subs: Heaton, Taylor, Vokes, Barnes, Gibson, Walters, Bardsley
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