Brighton are above the relegation zone on goal difference alone following a three-game losing run, while Southampton could be just four points above the drop if results go against them this weekend.
Here, Sports Mole rounds up all of the latest team news for the two clubs.
Sports Mole's predicted XI: Forster; Walker-Peters, Bednarek, Vestergaard, Bertrand; Armstrong, Diallo, Ward-Prowse, Minamino; Adams, Tella
BRIGHTON & HOVE ALBION
Sports Mole's predicted XI: Sanchez; Veltman, White, Dunk, Burn; Mac Allister, Bissouma, Gross; Trossard, Lallana; Maupay
Watch the Sports Mole Football Shorts prediction for this game below: