Forward Podence and defender Boly both missed the 0-0 draw with Leicester on Sunday due to injury and have been ruled out by boss Nuno Espirito Santo for this contest and the Premier League trip to Southampton on Sunday.
Kyle Walker-Peters is available for Southampton.
The defender has missed the last four games with a thigh problem while Ibrahima Diallo could also be fit following a muscle injury.
Liverpool loanee Takumi Minamino is unable to play under the terms of his move and Will Smallbone (knee), Theo Walcott (thigh) and Alexandre Jankewitz (banned) are out with Stuart Armstrong still battling a muscle issue.
Southampton provisional squad: McCarthy, Forster, Bednarek, Walker-Peters, Stephens, Bertrand, Ward-Prowse, Diallo, Armstrong, Djenepo, Ramsay, N'Lundulu, Ferry, Watts, Vokins, Adams, Ings, Redmond.
Wolves provisional squad: Patricio, Ruddy, Ait-Nouri, Hoever, Coady, Jonny, Saiss, Semedo, Kilman, Richards, Longwijk, Neves, Gibbs-White, Vitinha, Moutinho, Dendoncker, Otasowie, Neto, Jose, Silva, Traore.