Murphy was given the nod to start alongside Nathan Redmond and Tammy Abraham for Friday's goalless draw with Sweden Under-21s, but Reading's Swift has been brought into the XI in the only alteration from the first match.
As for Slovakia, Pavel Hapal's side are unchanged from their 2-1 win over Poland Under-21s last time out, meaning that top scorer Adam Zrelak leads the line with support from Jaroslav Mihalik and Albert Rusnak.
Slovakia Under-21s: Chovan; Valjent, Skriniar, Ninaj, Mazan; Lobotka, Chrien, Bero; Mihalik, Zrelak, Rusnak
Subs: Rodak, Jukubech, Huk, Vestenicky, Spalek, Satka, Skovajsa, Haraslin, Safranko, Vavro, Kacer, Benes
England Under-21s: Pickford; Holgate, Chambers, Mawson, Chilwell; Swift, Ward-Prowse, Chalobah, Redmond; Baker; Abraham
Subs: Gunn, Mitchell, Stephens, Gray, Targett, Murphy, Holding, Hause, Iorfa, Hughes, Grealish, Woodrow