Keller said that the key thing for the game would be for Schalke to take the confidence from the 3-0 win against Hamburger SV and get an early advantage over a rival for the European places.
"With the fans behind us and the added confidence boost following the Hamburg game, we are aiming to beat Wolfsburg," Keller told Bundesliga.com. "It's a really important game.
"They're one of our main rivals, but it's not the be-all and end-all. It won't really tell you much if we go four points clear of the Wolves because there are still another 15 games to play."
Schalke are currently fifth in the Bundesliga, with Wolfsburg a point and one place below.