Inter were involved in an exhausting match with Tottenham Hotspur, and Sampdoria manager Delio Rossi will know that their opponents may not be at 100%.
Fifth-placed Inter put up a tremendous fight in Europe on Thursday night, only to bow out on away goals after extra time.
Boss Andrea Stramaccioni would have been elated with his side's performance, but it remains to be seen whether he will freshen his side up on Sunday evening.
Midfielder Ricardo Alvarez could be in contention to start after coming off the bench to score on Thursday.
Inter Milan: DWLLW
Possible starting lineups
Sampdoria: Romero; De Silvestri, Rossini, Costa; Munari, Palombo, Poli, Pedro Obiang, Estigarribia; Eder, Icardi
Inter Milan: Handanovic; Zanetti, Chivu, Jonathan, Juan; Cambiasso, Gargano, Guarin, Kovacic; Palacio, Cassano
Sports Mole says: 1-2