Sami Khedira, back to fitness after being out since November with damaged knee ligaments, is handed a surprise start at the Estadio da Luz in Lisbon.
David Villa is the only man in this side to win the Champions League previously, having lifted the trophy with Barcelona.
Real Madrid: Casillas; Carvajal, Ramos, Varane, Coentrao; Khedira, Modric, Di Maria; Bale, Benzema, Ronaldo
Subs: Lopez, Pepe, Marcelo, Arbeloa, Isco, Illarramendi, Morata
Atletico Madrid: Courtois; Juanfran, Godin, Miranda, Filipe Luis; Gabi, Tiago, Koke, Garcia; Villa, Costa
Subs: Aranzubia, Alderweireld, Suarez, Rodriguez, Sosa, Diego, Adrian