The 30-year-old joined the Nerazzurri from rivals AC Milan earlier this week in a deal that included Giampaolo Pazzini moving the other way.
Walter Gargano also starts for the visitors having signed on a season-long loan from Napoli.
Alessandro Crescenzi is the only man missing for the home side, who lineup in a 4-3-3 formation.
Pescara: Perin; Zanon, Cascione, Capuano, Romagnoli; Balzano, Weiss, Colucci; Nielsen, Jonathas, Caprari
Inter: Castellazzi; Zanetti, Silvestre, Ranocchia, Nagatomo; Gargano, Cambiasso, Guarin; Sneijder, Cassano; Milito